... A case of severe hypotension and bradycardia following intravenous indigo carmine injection in a patient with known sulfa allergy /is reported/. Disodium (2e)-3-oxo-2-(3-oxo-5-sulfonato-1h-indol-2-ylidene)-1h-indole-5-sulfonate, 161. Graziano S et al; Int Urogynecol J Pelvic Floor Dysfunct 16 (5): 418-9 (2005). Drugs should be given only if the potential benefit justifies the potential risk to the foetus. ID: http://purl.bioontology.org/ontology/NDFRT/N0000148133. 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Yusim Y et al; J Clin Anesth 19 (4): 315-21 (2007). The product's dosage form is injection, solution, and is administered via intramuscular; intravenous form. [Na+], C1=CC2=C(C=C1S(=O)(=O)[O-])C(=O)/C(=C\3/C(=O)C4=C(N3)C=CC(=C4)S(=O)(=O)[O-])/N2.[Na+]. Ng TY et al; J Urol 116 (1): 132-3 (1976). Indigotine Conc. Hammann B.; Anaesthesist 38 (3): 136-9 (1989). After the HR was restored, 5 mL of saline was injected into the same artery, but no changes in hemodynamics were observed. Indigotin-5,5'-disulfonic Acid Disodium Salt, 62. The most commonly encountered cardiovascular effect of intravenous indigo carmine administration is transient a-receptor stimulation, which causes increases in peripheral vascular resistance, diastolic and systolic blood pressure, and central venous pressure, with compensatory decreases in cardiac output, stroke volume, and heart rate. 2. Patient 4 had a hypersensitivity reaction characterized by systemic urticaria and blue-colored subintegumentary edema due to the subcutaneous administration. 2-(1,3-dihydro-3-oxo-5-sulpho-2h-indol-2-ylidene)-3- Oxoindoline-5-sulphonic Acid, 10. Although the mechanism for hypotension with IC is unclear, we should be aware that IC, when given vaginally as well as IV, could cause severe hypotension. Indigo carmine was metabolized by cecal microflora /of rats/ to four [corrected] fluorescent metabolites with Rf values of 0.09, 0.27, 0.5 and 0.72 ... disodium;(2E)-3-oxo-2-(3-oxo-5-sulfonato-1H-indol-2-ylidene)-1H-indole-5-sulfonate. ... 4 patients ... had facial color changes to a blue-green-gray color and decreased oxygen saturation as measured by pulse oximetry. Although it is considered pharmacologically inert, it can cause significant problems, some of which are very important for anesthesiologists. Two (Patients 2 and 3) had hypotension, and one (Patient 3) required IV ephedrine to restore hemodynamic stability. 2-(1,3-dihydro-3-oxo-5-sulfo-2h-indol-2-ylidene)-2,3-dihydro-3-oxo-1h-indole-5-sulfonic Ac Id, Disodium Salt, 163. Disodium 3,3'-dioxo-(delta2,2'-biindoline)-5,5'-disulfonate, 91. It has a role as a food colouring and a histological dye. Erratum in: Biochem Biophys Res Commun 197 (1): 351 (1993). InChI=1S/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2/b14-13+;; C1=CC2=C(C=C1S(=O)(=O)[O-])C(=O)C(=C3C(=O)C4=C(N3)C=CC(=C4)S(=O)(=O)[O-])N2.[Na+]. Patient with heart rate and conduction disorders, hypertension, coronary disorders. Powered by CIMSAsia.com, Asia's one-stop resource for medical news, clinical reference and education. Ergotamine-like effects of indigo carmine due to direct vasoconstriction with spasm of the cerebral arteries are discussed. Indigo carmine is not recommended during pregnancy and in women of childbearing potential not using contraception. Indigo Carmine may interact with other drugs. 2,2'-bi(2,3-dihydro-3-oxoindolylidene)-5,5'-disulfonic Acid Disodium Salt, 158. It is unknown whether indigotin (indigo carmine) or its metabolites are excreted in human milk. The appearance of IC in the patient urine should suggest that surgical manipulation for multiple submucosal myoma could damage the endometrium, and thus predisposed local absorption of IC. Copyright © 2020 MIMS Pte Ltd. All rights reserved. Disodium 2,2'-bi(2,3-dihydro-3-oxoin Dolylidene)-5,5'-disulfonate, 156. Copyright © 2020 CIMS. Indigo carmine is approved by the US Food and Drug Administration (FDA) to localize ureteral orifices during cystoscopy and is commonly used in obstetrics and gynecology as a marker dye in the following additional situations: administered in a dilute solution via a … All rights reserved. It should be kept in mind that according to the literature, indigo carmine has severe side-effects on the cardiovascular system caused by vasoconstriction. Preferred Name: INDIGO CARMINE. Sporadic cases of untoward reactions to indigo carmine (IC) following its intravenous administration - mainly hypertension and bradycardia, but also, vomiting, and rare idiosyncratic reactions such as rash. ATC Classification . It is a member of indolones, an olefinic compound, an enone, an arenesulfonic acid and a ring assembly. Uncontrolled heart failure, history of allergic reactions, haemodynamic instability. The use of any information on this site is solely at your own risk. The intravenous method is preferred because a 5 mL injection is sufficient.