But it’s important to understand th… 3. Sorry, your blog cannot share posts by email. Stat Facts Sample-size calculation Cochrane Database Syst Rev. Data collection and analysis: Antifibrotics in liver disease: are we getting closer to clinical use? Cochrane database of systematic reviews (Online). Get the latest public health information from CDC: https://www.coronavirus.gov. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Liver-related mortality was significantly reduced by milk thistle in all trials (RR 0.50, 95% CI 0.29 to 0.88), but not in high-quality trials (RR 0.57, 95% CI 0.28 to 1.19). (2007). Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Here’s how to learn more facts about milk thistle. On further discussion with Thanh, he had not experienced any subjective benefit from milk thistle and was happy to stop using it. JAMA.2012;308(3):274–282. HHS This herb is believed to have possible benefits on liver health due to its antioxidant and free radical fighting properties, although no … He is actively involved in mental health policy, strategy, and governance, with local, state, and national bodies. doi: 10.1002/14651858.CD003045.pub2. Our results question the beneficial effects of milk thistle for patients with alcoholic and/or hepatitis B or C virus liver diseases and highlight the lack of high-quality evidence to support this intervention. Background: Thanh, a 35-year-old pharmacist with chronic hepatitis B, consulted with me recently. USA Phone: 215.489.4900 (PDF). There was little heterogeneity in the results as presented, though given the small number of studies, there were not many direct comparisons. Authors' conclusions: Our results question the beneficial effects of milk thistle for patients with alcoholic and/or hepatitis B or C virus liver diseases and highlight the lack of high-quality evidence to support this intervention. Radio interview on 2UE Healthy Lifestyle program, Quotation in “Health resolutions need the support of family and loved ones”, Dec In people who do not have a vitamin B deficiency and have adequate dietary intake, extra amounts provided by supplements simply pass from the body in the urine. 4. eCollection 2017. COVID-19 is an emerging, rapidly evolving situation. In people living with alcoholic liver disease, and/or viral induced liver diseases (hepatitis B and/or C) (Participants); what is the effect of milk thistle or any milk thistle constituent at any dose or duration (Intervention); compared to placebo or no intervention (Comparator); on several outcome measures including, (i) death, (ii) development of hepatitis clinical symptoms and complications (e.g., ascites, variceal bleeding), (iii) liver biochemistry, (iv) liver biopsy findings, and (v) adverse events (Outcome). Due to mixed literature and lack of proven improvements, patients should not rely on silymarin as a treatment for hepatitis B or D, and should discuss any new prescription recommendations with their doctor. Alcohol and hepatotoxic viruses cause the majority of liver diseases. Of the included studies, only one was specifically in people with hepatitis B, and there were fewer than 30 participants in that study. ; Chronic hepatitis B lasts for at least six months. The precautionary principle should apply and milk thistle products cannot be recommended for chronic hepatitis B. Adv Ther. Rusu, E., Jinga, M., Enache, G., Rusu, F., Dragomir, A. D., Ancuta, I., Draguţ, R., Parpala, C., Nan, R., Sima, I., Ateia, S., Stoica, V., Cheţa, D. M., Radulian, G. (2013). However, results from small clinical trials of milk thistle for liver diseases have been mixed, and two rigorously designed studies found no benefit.”. Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. 2016, This article was published in the December 2016 edition of Medical Observer, under the title, “Does milk thistle do any good?” (pp. Epub 2018 Oct 9. Studies with too few participants have low statistical power and thus a lower chance of detecting a true effect. doi:10.1001/jama.2012.8265. Milk Thistle is also known as “liver tonic” and rightly so as it only aims at strengthening the liver and all its functions. I knew that milk thistle is commonly marketed for “liver health” and wondered what the evidence was. Interventions encompassed milk thistle at any dose or duration versus placebo or no intervention. Fried MW, Navarro VJ, Afdhal N, et al. The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and full text searches were combined (July 2007). Rambaldi, Andrea & P Jacobs, Bradly & Gluud, Christian. Hepatol Int. But a 2013 study on hepatitis C patients unsuccessfully treated with interferon (the standard treatment for hepatitis B and D coinfection) found no significant difference in silymarin’s ability to lower ALT scores over placebo, a pill with no active drug ingredients 2 .